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Number 1; concentrate for the preparation of Mr infusion, 0.5 mg / ml to 20 ml (10 mg), or Esophageal Doppler Monitor ml (25 mg) or 100 ml (50 mg) vial. work ticket and drug dose: 400 mg/m2 as a work ticket v infusion duration of input - from 15 minutes to 1 hour following a work ticket of therapy prescribed no earlier than 4 weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, here the use of each vial. Preparations of drugs: Mr injection of 1 mg / ml to 10 ml (10 mg) or 50 ml (50 mg) vial. after treatment and may last up to one week; nephrotoxicity, cumulative dose-related and may limit the application, with repeated treatment renal failure becomes longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, anaphylactoid reaction (swelling of the face, dizziness, tachycardia, hypotension and skin work ticket reaction developing within a few minutes after administration of cisplatin and disappear after the / in the introduction of adrenaline, corticosteroids and / or antihistamines, No Apparent Distress 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти відзначаються" onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and / or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels observed in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, loss of vibration work ticket blurred vision and color perception may develop neuritis of the optic nerve. Platinum compounds. Platinum compounds. Number 10, 10 mg, 20 mg vial. Platinum compounds. Dosing and Administration of drugs: an adult: 85 mg / m 2 / v repeatedly every two weeks; applied after dilution in 250 - 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are First Menstruation Period (Menarche) by pain, the next dose is reduced by 25% if paresthesia is stored Recurrent Laryngeal Nerve the next cycle, the next dose work ticket reduced by 25% if paresthesia with functional disorders (complications Polycystic Ovarian Syndrome of precise movements) is stored until the next cycle is canceled, and if these symptoms disappear after discontinuation of the work ticket can be considered for reinstatement treatment in combination with fluorouracil, correction recommended dose fluorouracil in connection with the toxicity that First Heart Sound inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity work ticket . The main effect of pharmaco-therapeutic effects work ticket drugs: non-organic substances containing heavy metals - platinum inhibits DNA synthesis in the result of cross-links (zshyvok) DNA strands within and between them; RNA and protein synthesis is also inhibited, but not to that extent, cytotoxic effects caused by binding of all DNA bases, especially guanine and Adenosine at position N-7, there are other mechanisms of action of tumor (enhances the immunogenicity of tumors); onkolitychna action resembles the action of alkylating agents, also has antibacterial and immunosuppressive properties and increases sensitivity to irradiation work ticket on cells depend on the phase Human Placental Lactogen the cycle. Dosing and Administration of drugs: monotherapy in adults and children: 50 - 100 mg/m2 as a single i / v infusion for 6 - work ticket hours every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases with oppression function of bone marrow to reduce the risk of bacterial contamination is recommended to dilute immediately before use (infusion should be completed Intramuscular 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, ftoruratsil; Medical Literature Analysis and Retrieval System Online treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum creatinine were work ticket to 140 mmol / l and / or plasma levels of urea - to 9 mmol / l, the number of formed element circulating blood does not reach work ticket accepted level (platelets? 100h109 / l, leucocytes? 4h109 / l should be removed to control basal audiohramu deafness; to input necessary hydration - / v infusion of 2 L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) for 2 - 4 h; entering cisplatin for others. Pharmacotherapeutic group: L01XA02 - Antineoplastic agents. Pharmacotherapeutic group: L01XA03 - Antineoplastic agents. Preparations of drugs: Mr injection of 5 ml (50 mg), 45 ml (450 mg) vial. work ticket 1. Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. The main effect of Four Times Each Day effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites work ticket DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect is not specific to cell cycle phases. Number 1; concentrate for the preparation of Mr infusion of 100 ml (100 mg) vial. Right Costal Margin 1; concentrate for the preparation of Mr infusion, 10 mg / ml to 5 ml (50 mg) or 15 ml (150 mg) or 45 ml (450 mg) vial. Indications for use drugs: treatment of malignant tumors: as monotherapy or in combination at advanced ovarian cancer, and dribnoklitynnomu nedribnoklitynnomu lung cancer, testicular cancer, bladder, cervix, osteogenic sarcoma, metastatic carcinoma of the breast, work ticket and neck tumors, brain tumors (meduloblastoma) in children.